173) Answer

B. Hot flashes

Rationale

•Tamoxifen is an antineoplastic agent that competes with estrogen for binding sites. Hot flashes occur in over 60% of patients on tamoxifen.

•Side effects include hot flashes, vaginal bleeding, amenorrhea, menstrual changes, nausea, vomiting, rash, pruritus, osteoporosis, bone pain, and fractures.